Abstracts

Information biology

Rapid growth in numbering of known genes provokes to develop automated tools for their classification and analysis. In the last years, it becomes clear that nucleosome packaging of promoter gene regions is very important for gene functioning. Application of automated computer tools for nucleosome packaging density recognition in nucleosome regions in eukaryotes may be used for studying of the pattern of gene expression. An analysis was performed of nucleosome packaging density for human genes differing by expression patterns. The potential of nucleosome packaging DNA for promoters of genes with tissue-specific activity appeared to be essentially higher than that of genes expressed in many tissues or that of "housekeeping" gene promoters. This phenomenon counts in favor that one of the factors regulating gene expression pattern is ability of a gene promoter to nucleosome positioning. The program for nucleosomal sites recognition is included into the GeneExpress system, section DNA nucleosomal organization, http://wwwmgs.bionet.nsc.ru/mgs/programs/recon/.

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©2001, Siberian Branch of Russian Academy of Science, Novosibirsk
©2001, United Institute of Computer Science SB RAS, Novosibirsk
©2001, Institute of Computational Techologies SB RAS, Novosibirsk
©2001, A.P. Ershov Institute of Informatics Systems SB RAS, Novosibirsk
©2001, Institute of Mathematics SB RAS, Novosibirsk
©2001, Institute of Cytology and Genetics SB RAS, Novosibirsk
©2001, Institute of Computational Mathematics and Mathematical Geophysics SB RAS, Novosibirsk
©2001, Novosibirsk State University
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