Abstracts

Cybernetics and Phisiology

Russian specialists of aviation and space medicine more than 30 years conduct the experimental physiological and clinical researches about the influence of gravitational factor on the human organism. In particular, the scientific investigations of the State Research Center RF - Institute of Biomedical Problems have brought the fundamental contribution to the theory of gravitational biology (Gazenko O. G., Grigoriev A.I., 1998). In the basis of organism life the adaptation to the gravitation field of a planet is included. The orientation in relation to force of gravitation is executed by means of functional system of antigravitation, described by Belkanya G. S. et al. (1982). In earlier researches the perspectiveness of study of a role of regulation changes in cardiovascular system depending on strain level of functional system of antigravitation in essential arterial hypertension's pathogenesis was already determined.

The investigations data of 12 pilots of civil aviation are surveyed. All pilots were admitted to flight activity and carrying out regular flights via Earth meridians. All outpatient examinations were carried out in days between flights.

To the pilots were carried out: 24-hour ECG monitoring (2-channel recorder of HOLTER Sistem МТ-100/200, "SCHILLER") and 24-hour ambulatory blood pressure monitoring (recorder BR-102, "SCHILLER") with realization of auscultation and oscillometric methods of blood pressure measurement; active orthostatic test during 30 minutes with registration ECG and blood pressure (oscillometric methods of blood pressure measurement) by the bedside monitor "Life Scope 9" ("NIHON KOHDEN") and measurement of heart rate variability with a hardware-software complex "VARICARD" ("RAMENA"). All pilots passed thru complete diagnostic investigation during annual medical examination and had the clinical diagnosis - an essential arterial hypertension.

At the pilots with essential arterial hypertension the decrease of diurnal meanings of statistical parameters reflecting a low-frequency wave spectrum of heart rate variability at their relative increase on 40-55% in morning 5-hour period from 5:00 up to 10:00 a.m. are observed. At a clinical estimation of heart rate variability by the data of 24-hour ECG monitoring the important meaning has relative increase SDANN (Standard Deviation of the Average RR intervals calculated over 5 minutes) in morning 5-hour period from 5:00 up to 10:00 a.m., reflecting the maximal physiological activation in functional system of antigravitation during round the clock. At absence of relative increase of this parameter in the morning period it is possible to predict unsatisfactory stability at active orthostatic test with inadequate dastolic blood pressure increase at the pilots with essential arterial hypertension.

By the data of the correlation analysis, carried out by us, it's possible to assume, that the decrease of power of oscillations Ultra Low Frequency (which reflect the regulation by central contour of management of heart rhythm including basal ganglions of hemispheres frames of a brain, and by renin-angiotensin-aldosterone system) at orthostasis at the pilots with essential arterial hypertension accompanies increase of systemic vascular resistance, and that the renin-angiotensin-aldosterone system activation at orthostasis directly depends on its background activity during daily period, particularly in the night period, which is a most vulnerable for vascular system. The data of the correlation analysis confirm necessity of a complex estimation of heart rate variability both at 24-hour ECG monitoring and at active orthostatic test.

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